I tend to wake up in a rather fine mood mood the day after but I do half some side effects for a couple hour s after using it. For the first couple hours the next day I tend to be slightly out of balance with my body movements a small equilibrium issue nothing major just kinda clumsy a little, but you have to take in my i usually take 4 times the suggested dosage on a MXE night...but it definitely helps with my depression for a few days. I'd need to try popping a antidepressant before bed after using MXE and see if that even further helps with depression. nomad bloodbath